CBE

Dr. Lalita Kanwar Shekhawat

Dr. Lalita Kanwar Shekhawat
Assistant Professor
PhD (Chemical Engineering), IIT Delhi (2019)
+91-612-302-8985
lalita@iitp.ac.in
Research Areas

  • Bioprocessing and Bioseparation: Downstream processing of therapeutic proteins; Development and optimization of chromatographic purification of monoclonal and bispecific antibodies; Quality by design: Design of Experiments and High-throughput process development, Mechanistic modeling of chromatographic separation process, Process analytical Tools (PATs), Computational fluid dynamics (CFD)
Other Interests
    • Biomedical biosensor development for early detection of cancer disease
    • Upstream bioprocessing of biotherapeutics
    • Artificial neutral networks application in downstream processing of biotherapeutics
    • Lab scale development of crystallization process development and optimization for Active Pharmaceutical Ingredients (APIs) and its scale-up
Courses taught at IIT P
    • Fluid Mechanics
    • Transport Phenomena
    • Mechanical Operations
    • Chemical Process Technology
    • Process Plant Design and Economics
    • Petroleum Refinery and Petrochemicals

     
Professional Experience

  •  Post-doc Scientist  (March 2019 –March 2020) and Scientist in Cytiva, Uppsala, Sweden (April 2020 –August 2023)

    ~ 3 years work experience in Dr. Reddy’s Laboratories, Hyderabad as Scientist

       Projects handled:

    • Crystallization process developed for two Active Pharmaceutical Ingredients (APIs): (i) Bazedoxifene acetate and (ii) Linagliptin at lab scale and scaled up the process up to 2kg in plant.
    • Scale-up of the process from lab to plant scale accomplished using Design of experiments (DOE) as Quality by Design (QbD) tool.
    • Patent published for novel polymorph for both APIs: 1. WO2012037187A3: Preparation of crystalline bazedoxifene and its salts; https://patents.google.com/patent/WO2012037187A2/en 2. WO2013128379A2: Crystalline polymorphic forms of linagliptin; https://patents.google.com/patent/WO2013128379A2/en

    ~1.5 year Industrial experience (as graduate engineer trainee at GE Plastics, Bangalore – John F. Welch Technology Center)

    Projects handled:

    • Experimental study of effect of catalyst impurities on reaction yield (for Chlorophthalic anhydride production from Chloroxylene) – this has potential to save fresh catalyst usage in plant by recycle.
    • Screening different adsorbents for adsorbing chlorophthalic anhydride vapours. This screens potential process options for environment safety factors.
Administrative Experience
    • Extra-Academic Activities:

               (a) Pursuing the responsibility of Hostel Warden of Aryabhatta Wing C

               (b) Pursuing the responsibility of Faculty Advisor in CBE department

               (c) Pursuing the responsibility of Mess committee member for mess 6
Awards & Honours

  •  

    SL. No.

    Name of Award

    Award Agency

    Year

    1.

    CHEMICAL ENGINEERING ASSOCIATION AWARDS,

    Class topper for exam held in June/July for academic year 2004-2005

    Department of Chemical Engineering, Dayananda Sagar College of Engineering (D. S. C. E.), Bangalore

    2004-2005

    2.

    CHEMICAL ENGINEERING ASSOCIATION AWARDS

    Class topper in Petrochemicals exam held in June/July for academic year 2004-2005

    Department of Chemical Engineering, Dayananda Sagar College of Engineering (D. S. C. E.), Bangalore

    2004-2005

    3.

    CHEMICAL ENGINEERING ASSOCIATION AWARDS,

    Class topper for 5th semester exam held in academic year 2003-2004

    Department of Chemical Engineering, Dayananda Sagar College of Engineering (D. S. C. E.), Bangalore

    2003-2004

    4.

    CHEMICAL ENGINEERING ASSOCIATION AWARDS

    Class topper in Mass Transfer I exam held in academic year 2003-2004

    Department of Chemical Engineering, Dayananda Sagar College of Engineering (D. S. C. E.), Bangalore

    2003-2004

    5.

    Chemical Weekly Award

    IIChE-Award

    2013-2014

    6.

    IIChE NRC Award

    IIChE-Award

    2013-2014

    7.

    Kuloor Memorial Award

    IIChE-Award

    2013-2014

    8.

    APRECIATION AWARD, U2 CLOX OXIDATION PROJECT for HPP Program

    CEPT Leadership, GE Plastics

    2007

    9.

    BEST IDEA GENERATION, IPDO AWARDS

    Dr. Reddy’s Laboratories Ltd

    2011

    10.

    Gold Medalist award for scoring first rank in B.E. (Chemical Engineering) for the year 2005

    VISVESWARAIAH TECHNOLOGICAL UNIVERSITY, BELGAUM

    2005
Member of Professional bodies
    • Bioprocessing India (Lifetime membership)
Books
    1. Book Chapter: Rathore, A. S., Shekhawat, L. K., Loomba, V. (2016), Computational Fluid Dynamics for Bioreactor Design. In Carl-Fredrik Mandenius (Eds.), Bioreactors: Design, Operation and Novel Applications (pp. 295-320), John Wiley & Sons, Germany.
Patents
Publications / Journals / Conferences

  • Journal Publications:

    1. Rohit, Kanwar, L., Rao, K. K. (2010). Development of a low-cost portable colorimeter for the estimation of fluoride in drinking water. Sensors and Actuators B: Chemical, 149(1), 245-251.
    2. Shreyas, L., Kanwar, L., Rao, K. K. (2013). Chemical Engineering and the Mitigation of Fluorosis. Indian Chemical Engineer, 55(1), 38-49
    3. Shekhawat, L. K., Manvar, A. P., Rathore, A. S. (2016). Enablers for QbD implementation: Mechanistic modeling for ion-exchange membrane chromatography. Journal of Membrane Science, 500, 86-98.
    4. Sarkar, J., Shekhawat, L. K., Loomba, V., Rathore, A. S. (2016). CFD of mixing of multi‐phase flow in a bioreactor using population balance model. Biotechnology progress, 32(3), 613-628.
    5. Shekhawat, L. K., Chandak, M., & Rathore, A. S (2017). Mechanistic modeling of hydrophobic interaction chromatography for monoclonal antibody purification: Process optimization in the quality by design paradigm. Journal of Chemical Technology and Biotechnology. 92(10), 2527-2537.
    6. Ramakrishnan, S., Yarraguntla, S. R., Peddireddy, S. R., Kanniah, S. L., Mudapaka, V. K., Shekhawat, L. K., Stephens, P. W. (2017). Development of Pharmaceutically Acceptable Crystalline Forms of Drug Substances via Solid-State Solvent Exchange. Organic Process Research and Development, 21(10), 1478-1487.
    7. Shekhawat, L. K., Sarkar, J., Gupta, R., Hadpe, S., Rathore, A. S. (2017). Application of CFD in bioprocessing: Separation of mammalian cells using disc stack centrifuge during production of biotherapeutics. Journal of Biotechnology, 267, 1-11.
    8. Shekhawat, L. K., Pathak, M., Sakar, J., Rathore, A. S. (2018). Process development in the QbD paradigm: Modeling of Protein-A chromatography resin fouling. Journal of Chromatography A 1570, 56-66. DOI:10.1016/j.chroma.2018.07.060.
    9. Shekhawat, L. K., Godara, A., Kumar, V., Rathore, A. S. (2018). Design of Experiments Application in Bioprocessing: Chromatography process development. Biotechnology Progress. DOI:10.1002/btpr.2730
    10. Shekhawat, L. K., Rathore, A. S. (2019). Mechanistic modeling based process analytical technology implementation for pooling in hydrophobic interaction chromatography. Biotechnology Progress. 35(2), p.e2758
    11. Shekhawat, L. K., Rathore, A. S. (2019). An overview of mechanistic modelling of liquid chromatography. Preparative Biochemistry and Biotechnology 49, 623-638. DOI: 10.1080/10826068.2019.1615504
    12. Nair, A.M., Dhawangale, A., Chandra, S., Shekhawat, L.K., Rathore, A.S. and Mukherji, S. (2020). Polymer-coated fiber optic sensor as a process analytical tool for biopharmaceutical impurity detection. IEEE Transactions on Instrumentation and Measurement, 69(10), 7666-7674.
    13. Shekhawat, L. K., Tiwari, A., Yamamoto, S., & Rathore, A. S. (2022). An accelerated approach for mechanistic model based prediction of linear gradient elution ion-exchange chromatography of proteins. Journal of Chromatography A, 1680, 463423.
    14. Shekhawat, L. K., Markle, T., Esfandiarfard, K., Theel, E. K., Maloisel, J. L., & Malmquist, G. (2023). Next generation multimodal chromatography resins via an iterative mapping approach: Chemical diversity, high-throughput screening, and chromatographic modelling. Journal of Chromatography A, 1699, 464018.
    15. Hahn, T., Trunzer, T., Rusly, F., Zolyomi, R., Shekhawat, L. K., Malmquist, G., Tjandra, H. (2024). Predictive scaling of fiber-based protein A capture chromatography using mechanistic modeling. Biotechnology and Bioengineering, 121(8), 2388-2399.
Presentations
    • Shekhawat, L. K., Manvar, A. P., Rathore, A. S. (2016). Enablers for QbD implementation: Mechanistic modeling for ion-exchange membrane chromatography. Journal of Membrane Science, 500, 86-98. [poster presentation in Bioprocessing India 2015  in IIT Madras, India]
    • Shekhawat, L. K., Manvar, A. P., Rathore, A. S. (2016). Enablers for QbD implementation: Mechanistic modeling for ion-exchange membrane chromatography. Journal of Membrane Science, 500, 86-98. [oral presentation in 253rd ACS National Meeting in San Francisco, California]
    • Sarkar, J., Shekhawat, L. K., Loomba, V., Rathore, A. S. (2016). CFD of mixing of multi‐phase flow in a bioreactor using population balance model. Biotechnology progress, 32(3), 613-628. [poster presentation in 253rd ACS National Meeting in San Francisco, California]
    • Shekhawat, L. K., Godara, A., Kumar, V., Rathore, A. S. (2019). Design of Experiments Application in Bioprocessing: Chromatography process development. Biotechnology Progress, 35(1), p.e. 2730. [poster presentation in 253rd ACS National Meeting in San Francisco, California]
    • Shekhawat, L.K., Keyhan Esfandiarfard, Eike Kristian Theel, Todd Markle, Jean-Luc Maloisel, Gunnar Malmquist (2020). Next generation multimodal chromatography resins via an iterative mapping approach: chemical diversity, high-throughput screening, and chromatographic modelling. [paper presentation in 259th ACS National Meeting in Philadelphia, Pennsylvania]
    • Shekhawat, L.K., Todd Markle, Jean-Luc Maloisel, Gunnar Malmquist (2021). Mechanistic modeling of multimodal chromatography for a separation of a monoclonal antibody from product-related impurities: Fab fragment and aggregates. [paper presentation in 262th ACS National Meeting in Atlanta, Georgia]
    • Shekhawat, L.K., Todd Markle, Jean-Luc Maloisel, Gunnar Malmquist (2021). Mechanistic modeling of multimodal chromatography for a separation of a monoclonal antibody from product-related impurities: Fab fragment and aggregates. [paper presentation in 87th International Chemical Engineering Symposia 2022, SCEJ, Japan]
    • Hahn, T., Trunzer, T., Rusly, F., Zolyomi, R., Shekhawat, L.K., Malmquist, G., Hesslein, A. and Tjandra, H. (2024). Predictive scaling of fiber‐based protein A capture chromatography using mechanistic modeling. [paper presentation in COE CBT Course series 2023, IIT Delhi, India]
Invited Talks
    • Shekhawat, L.K., Todd Markle, Jean-Luc Maloisel, Gunnar Malmquist (2021). Mechanistic modeling of multimodal chromatography for a separation of a monoclonal antibody from product-related impurities: Fab fragment and aggregates. [paper presented as a key speaker in 87th International Chemical Engineering Symposia 2022, SCEJ, Japan]
    • Hahn, T., Trunzer, T., Rusly, F., Zolyomi, R., Shekhawat, L.K., Malmquist, G., Hesslein, A. and Tjandra, H. (2024). Predictive scaling of fiber‐based protein A capture chromatography using mechanistic modeling. [paper presented as a key speaker in COE CBT Course series 2023, IIT Delhi, India]
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